Flow chemistry Set-up Enables Integration of Chemo- and Biocatalysis

Pablo Díaz-Kruik; Stefania Gianolio; Francesca Paradisi

doi:10.2533/chimia.2023.307

Flow chemistry Set-up Enables Integration of Chemo- and Biocatalysis

Authors

Pablo Díaz-Kruik Dept. Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern https://orcid.org/0000-0001-5829-9437
Stefania Gianolio Dept. Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern
Francesca Paradisi Dept. Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern https://orcid.org/0000-0003-1704-0642

DOI:

https://doi.org/10.2533/chimia.2023.307

PMID:

38047826

Keywords:

Biocatalysis, Enzymes, Flow chemistry, Sustainability

Abstract

The move towards sustainable syntheses is a widespread effort which sees academia and industry developing new strategies and solutions. Flow chemistry, and in general the flow set up, with the compartmentalization of different steps in dedicated reactors, offers new possibility to integrate biocatalytic steps within a chemical cascade, often without the need to redesign the whole pathway. Here we report key examples in the field over the past few years.