Evolution of Solid Processing Methods in Continuous Flow Technology: Reactive Extrusion

Jamie A. Leitch; Paul Richardson; Duncan L. Browne

doi:10.2533/chimia.2023.339

Evolution of Solid Processing Methods in Continuous Flow Technology: Reactive Extrusion

Authors

Jamie A. Leitch Department of Pharmaceutical and Biological Chemistry, UCL, School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX https://orcid.org/0000-0001-6997-184X
Paul Richardson Pfizer Inc., 10555 Science Center Drive, San Diego, CA92121
Duncan L. Browne Department of Pharmaceutical and Biological Chemistry, UCL, School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX

DOI:

https://doi.org/10.2533/chimia.2023.339

PMID:

38047830

Keywords:

Continuous Flow, Extrusion, Mechanochemistry, Solids

Abstract

The frustrations of precipitation, fouling and blockages of liquid-based flow reactors is familiar to all researchers that have worked with continuous flow equipment. There have been many innovative solutions to try and circumvent this issue. This short review will highlight the emerging technique of mechanochemistry and reactive extrusion as a continuous process that can directly work on solid (and liquid) materials and elicit chemical transformations.