Visible Light Induced One-pot Synthesis of Spirocyclopropyl Oxindoles from Isatin Derivatives and Glycine Ester Hydrochloride

Authors

  • Subhankar Bera Shiv Nadar Institution of Eminence Deemed to be University, Dehli-NCR, India.
  • Tejas Prabakar Shiv Nadar Institution of Eminence Deemed to be University, Dehli-NCR, India.
  • Khushi Verma Shiv Nadar Institution of Eminence Deemed to be University, Dehli-NCR, India.
  • Subhabrata Sen Shiv Nadar Institution of Eminence Deemed to be University, Dehli-NCR, India.

DOI:

https://doi.org/10.2533/chimia.2025.639

PMID:

40936240

Keywords:

Alkyl diazo ester, Alkylidene oxindole, Blue LED, Spirocyclic oxindole

Abstract

An integrated one pot protocol for the in situ generation of hazardous alkyl diazoacetates (from glycine ester hydrochloride) and their subsequent reaction with 3-alkenyl oxoindoles (generated via the in situ Wittig reaction from isatin derivatives) to afford diastereomeric mixtures of spirocyclopropyl oxoindoles in toluene at room temperature is presented. Spirocyclopropyl oxoindoles are interesting building blocks prevalent in many active pharmaceutical ingredients and in natural products. This protocol is devoid of any metal catalysts or bases.

CHIMIA Vol. 79 No. 9 (2025): Green & Sustainable Chemistry: Trends and Outlooks

Downloads

Additional Files

Published

2025-09-10

Issue

Vol. 79 No. 9 (2025): Green & Sustainable Chemistry: Trends and Outlooks

Section

Scientific Articles

License

Copyright (c) 2025 Subhankar Bera, Tejas Prabakar, Khushi Verma, Subhabrata Sen

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
S. Bera, T. . Prabakar, K. Verma, S. Sen, Chimia 2025, 79, 639, DOI: 10.2533/chimia.2025.639.