Eine neue Peptidsynthese: Abspaltung des o-Nitrophenylsulfenyl(NPS)-restes in situ während der Synthese mit Thiophenylestern

Abstract

Thiophenylesters of acylated aminoacids react in high yield with NPS-protected (NPS = o-Nitrophenylsulfenyl-) esters of amino acids to dipeptides and disulfides. The reaction depends strictly on catalysis of imidazole. Protected peptides were shown to react in the same manner. Under the same conditions yields were found better in the peptide synthesis with NPS-protected esters of amino acids than in the synthesis with unprotected esters of amino acids.