Conformationally Restricted Oligonucleotide Analogues 'Made in Bern': A Mini Review
Keywords:Conformational restriction, DNA, Nucleosides, Oligonucleotides, RNA
AbstractIn our search for novel oligonucleotide analogues for use in therapy and DNA-based diagnostics we explored the concept of conformational preorganization as a means to improve duplex stability with complementary DNA and RNA. This research effort has led to a number of novel DNA analogues and has contributed to a deeper understanding of the interrelation between the structure of nucleosides and the properties of corresponding oligonucleotides. Some of these analogues show interesting biological properties. This article is a short review summarizing the properties of bicyclo-DNA and tricyclo-DNA, developed in our laboratory.
How to Cite
C. J. Leumann, Chimia 2001, 55, 1041, DOI: 10.2533/chimia.2001.1041.
Copyright (c) 2001 Swiss Chemical Society
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