The Design and Synthesis of Novel Muguet Fragrance Ingredients: The Discovery of a Series of 3-Alkylcycloalkanols
Keywords:3-alkylcycloalkanols, Fragrance ingredient, Molecular modelling, Muguet, Structure-activity relationships
AbstractA number of novel muguet fragrance ingredients have been discovered with the support of qualitative structure-activity relationships and molecular modelling. These belong to the following chemical families; 3-alkylcycloalkanols, 3-alkylcyclohexylmethanols and 4-(2-methylpropyl)cyclohexanols. It has also been shown that within the 3-alkylcycloalkanols, the alcohol group is not necessarily a prerequisite for a muguet odour, but that conversion to other functional groups does lead to weaker odorants. Chirality also appears to play an important role on the odour properties of 3-alkylcycloalkanols.
How to Cite
K. Rossiter, Chimia 2001, 55, 388, DOI: 10.2533/chimia.2001.388.
Copyright (c) 2001 Swiss Chemical Society
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