On-line Reaction Monitoring of Lithiation of Halogen Substituted Acetanilides via in situ Calorimetry, ATR Spectroscopy, and Endoscopy

Authors

  • Tamas A. Godany Institute for Chemical and Bioengineering, ETH Zürich, Wolfgang-Pauli Str. 10, HCI G130, CH-8092 Zürich
  • Yorck-Michael Neuhold Institute for Chemical and Bioengineering, ETH Zürich, Wolfgang-Pauli Str. 10, CH-8092 Zürich
  • Konrad Hungerbühler Institute for Chemical and Bioengineering, ETH Zürich, Wolfgang-Pauli Str. 10, CH-8092 Zürich

DOI:

https://doi.org/10.2533/chimia.2011.253

PMID:

21678773

Keywords:

Acetanilides, Calorimetry, Lithiation, On-line spectroscopy

Abstract

Lithiation of N-(4-chlorophenyl)-pivalamide (NCP) and two additional substituted acetanilides: 4-fluoroacetanilide (4-F) and 4-chloroacetanilide (4-Cl) has been monitored by means of calorimetry, on-line ATR-IR and UV/vis spectroscopy and endoscopy. The combined on-line monitoring revealed the differences between the reaction paths of the chosen substrates. Thus the product structure and the reaction times for the individual reaction steps can be determined in situ.

CHIMIA Vol. 65 No. 4 (2011): Laureates: Awards and Honors SCS Fall Meeting

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Published

2011-04-27

Issue

Vol. 65 No. 4 (2011): Laureates: Awards and Honors SCS Fall Meeting 2010

Section

Scientific Articles

License

Copyright (c) 2011 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
T. A. Godany, Y.-M. Neuhold, K. Hungerbühler, Chimia 2011, 65, 253, DOI: 10.2533/chimia.2011.253.