Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer
Keywords:Buruli ulcer, Diverted total synthesis, Mycolactone, Total synthesis
AbstractBuruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.
How to Cite
S. Saint-Auret, A.-C. Chany, V. Casarotto, C. Tresse, L. Parmentier, H. Abdelkafi, N. Blanchard, Chimia 2017, 71, 836, DOI: 10.2533/chimia.2017.836.
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