Engineering Aspects of Protein Interactions and Self-assembly

Authors

  • Miriam Linsenmeier ETH Zurich Department of Chemistry and Applied Biosciences Institute for Chemical and Bioengineering, Vladimir Prelog Weg 1, CH-8093 Zurich, Switzerland
  • Paolo Arosio ETH Zurich Department of Chemistry and Applied Biosciences Institute for Chemical and Bioengineering, Vladimir Prelog Weg 1, CH-8093 Zurich, Switzerland. paolo.arosio@chem.ethz.ch

DOI:

https://doi.org/10.2533/chimia.2018.304

Keywords:

Alzheimer's disease, Amyloids, Microfluidics, Protein aggregation, Protein interactions, Protein phase separation

Abstract

In the new Laboratory for Biochemical Engineering (LBCE) at ETH Zurich researchers combine principles of chemical engineering with microfluidic technology and biophysical methods to investigate the physical determinants of biomolecular self-assembly in living organisms. In this account, we show the impact of this activity on concrete applications in biomedical sciences and biotechnology. We focus in particular on the field of protein aggregation and phase separation, and we highlight examples in the context of diagnosis and treatment of Alzheimer's disease and neurodegenerative disorders, cell compartmentalization as well as manufacturing and delivery of therapeutic proteins.

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Published

2018-05-30