THQphos in Ir-catalyzed Asymmetric Allylic Substitution Reactions

Xiao Zhang; Shu-Li You

doi:10.2533/chimia.2018.589

THQphos in Ir-catalyzed Asymmetric Allylic Substitution Reactions

Authors

Xiao Zhang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China
Shu-Li You State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 300072, China;, Email: slyou@sioc.ac.cn

DOI:

https://doi.org/10.2533/chimia.2018.589

Keywords:

Allylic substitution, Asymmetric catalysis, Iridium, Thqphos

Abstract

The 1,2,3,4-tetrahydroquinoline phosphoramidites (THQphos) have been found to be efficient ligands for iridium-catalyzed asymmetric allylic substitution reactions. In this short review article, an overall introduction on the development of THQphos, involving their original design, preparation, mechanistic studies, applications and features will be described.