Interface-rich Aqueous Systems for Sustainable Chemical Synthesis

Authors

  • Dainis Kaldre Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel
  • Fabrice Gallou Chemical & Analytical Development, Novartis Pharma AG, CH-4056 Basel
  • Christof Sparr Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel;, Email: christof.sparr@unibas.ch
  • Michael Parmentier Chemical & Analytical Development, Novartis Pharma AG, CH-4056 Basel;, Email: michael.parmentier@novartis.com

DOI:

https://doi.org/10.2533/chimia.2019.714

PMID:

31514771

Keywords:

Cross-coupling, Interface-rich aqueous systems, Sustainability, Synthesis, Water

Abstract

Mimicking an enzyme's exquisite activity and selectivity is a long-standing goal for sustainable chemical method development in aqueous media. The use of interface-rich aqueous systems, such as single-chain polymers, micelles and vesicle membranes recently emerged as strategy to emulate the compartmentalization of natural systems. In aqueous solution, aggregates such as micelles or microemulsion droplets are formed, providing reaction environments different from bulk solutions that frequently improve selectivity and accelerate reaction rates for a wide array of chemical transformations. We present here selected examples of interface-rich aqueous systems and discuss the advantages they offer for chemical synthesis. In particular metal-catalyzed cross-coupling reactions are highlighted and future challenges to perform reactions in interface-rich aqueous media are discussed.

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Published

2019-09-18

How to Cite

[1]
D. Kaldre, F. Gallou, C. Sparr, M. Parmentier, Chimia 2019, 73, 714, DOI: 10.2533/chimia.2019.714.