Molecular Complexity for Chemical Reactions

Medicinal Chemistry and Chemical Biology Highlights

Authors

  • Modest von Korff Idorsia Pharmaceuticals Ltd, CH-4123 Allschwil
  • Thomas Sander Idorsia Pharmaceuticals Ltd, CH-4123 Allschwil

DOI:

https://doi.org/10.2533/chimia.2023.258

Keywords:

Molecular complexity, Natural product synthesis, Reactions, Strychnine

Abstract

A new method is presented on how to calculate molecular complexity for chemical reactions by the fractal dimension of educts and products. Two pathways for the total synthesis of strychnine were compared. Significant differences in the two synthesis pathways were reflected by reaction complexity. These results demonstrate that reaction complexity is a powerful measure to group chemical reactions beyond substructural changes.

CHIMIA Vol. 77 No. 4 (2023): Laureates: Junior Prizes of the Fall Meeting 2022

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Published

2023-04-26

How to Cite

[1]
M. von Korff, T. Sander, Chimia 2023, 77, 258, DOI: 10.2533/chimia.2023.258.

Issue

Vol. 77 No. 4 (2023): Laureates: Junior Prizes of the Fall Meeting 2022

Section

Columns, Conference Reports

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License

Copyright (c) 2023 Modest von Korff, Thomas Sander

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.