Tuning NaCo(II) Bimetallic Cooperativity to Perform Co–H Exchange / C–F Bond Activation Processes in Polyfluoroarenes

Authors

  • Alessandra Logallo Departement für Chemie und Biochemie (DCBP), Universität Bern, Freiestrasse 3, CH-3012, Bern, Switzerland
  • Eva Hevia Departement für Chemie und Biochemie (DCBP), Universität Bern, Freiestrasse 3, CH-3012, Bern, Switzerland

DOI:

https://doi.org/10.2533/chimia.2024.238

PMID:

38676617

Keywords:

Alkali metals, Amides, Ate complexes, Cobalt, Cooperativity

Abstract

Recent advances in cooperative chemistry have shown the potential of heterobimetallic complexes combining an alkali-metal with an earth abundant divalent transition metal for the functionalisation of synthetically relevant aromatic molecules via deprotonative metalation. Pairing sodium with cobalt (II), here we provide an overview of the reactivity of bimetallic [NaCo(HMDS)3] [HMDS = N(SiMe3)2] towards C-H and C-F functionalisation of a wide range of perfluorinated molecules. These studies also uncover the enormous potential of this heterobimetallic base to perform Co-H exchanges with excellent selectivity and exceptional stoichiometric control as well as shedding light on the key role played by the alkali-metal.

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Published

2024-04-24