From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents

Erwin Goetschi; Fabienne Ricklin; Peter Reindl; Raffaello Masciadri; Thomas Luebbers; Helmut Link; Dirk Kostrewa; Paul Hebeisen; Hans Gmuender; Peter Angehrn; Frank-Peter Theil

doi:10.2533/000942903777679505

From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents

Authors

Erwin Goetschi
Fabienne Ricklin
Peter Reindl
Raffaello Masciadri
Thomas Luebbers
Helmut Link
Dirk Kostrewa
Paul Hebeisen
Hans Gmuender
Peter Angehrn
Frank-Peter Theil

DOI:

https://doi.org/10.2533/000942903777679505

Keywords:

Antibacterials, Cyclothialidine, Dna gyrase inhibitor, Natural products

Abstract

Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.

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Published

2003-04-01

How to Cite

[1]

E. Goetschi, F. Ricklin, P. Reindl, R. Masciadri, T. Luebbers, H. Link, D. Kostrewa, P. Hebeisen, H. Gmuender, P. Angehrn, F.-P. Theil, Chimia 2003, 57, 184, DOI: 10.2533/000942903777679505.