Selective Release of Technetium Complexes from a Solid Phase due to C–N Bond Cleavage upon Metal Coordination

Authors

  • Stefan Mundwiler
  • Lukas Candreia
  • Roger Alberto

DOI:

https://doi.org/10.2533/000942903777679514

Keywords:

Cleavage reactions, Radiopharmaceuticals, Solid-phase synthesis, Technetium

Abstract

A new method for 99mTc-labeling using solid-phase technology is described. It allows the separation of unlabeled from labeled bioactive molecules by simple filtration. The procedure is based on a site-specific C–N bond cleavage reaction initiated by the formation of [TcI(CO)3L]-complexes.

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Published

2003-04-01

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