Chemo-Enzymatic Synthesis of Antagonists of the Myelin-associated Glycoprotein (MAG)
Keywords:Chemo-enzymatic synthesis, Myelin-associated glycoprotein (mag), Ratst3gal iii, Alpha(2 -3)-sialyltransferase
AbstractGanglioside GQ1b ? is the most potent antagonist of the Myelin-associated glycoprotein (MAG) identified so far. For the efficient synthesis of the partial structure of GQ1b ? and derivatives thereof, a chemo-enzymatic strategy using the ?(2?3)-sialyltransferase ratST3Gal III (EC 220.127.116.11) was applied. Besides the natural substrates Gal? (1?3)GlcNAc (19) and Gal? (1?4)GlcNAc (20), the disaccharides Gal? (1?3)GalNTCA?-OSE (9), Gal? (1?3)GalNAc?-OSE (11), and Gal? (1?3)Gal?-OSE (14) were also tolerated by the enzyme and were transformed to the target structures in preparative scale.
How to Cite
G.-P. Gao, O. Schwardt, T. Visekruna, S. Rabbani, B. Ernst, Chimia 2004, 58, 215, DOI: 10.2533/000942904777678019.
Copyright (c) 2004 Swiss Chemical Society
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