Brain Disorders and Novel Therapeutics
Keywords:Anxiety, Diazepam, Gaba, Gabaa receptor subtypes, Memory
AbstractUsing the power of genetic intervention, a strategy is illustrated which permits new insights into the pathobiology of brain diseases and the discovery of new therapeutic strategies. Brain function is based on a delicate balance between excitory and inhibitory neurotransmission. Selective circuits of GABAergic inhibitory transmission were targeted by introducing point mutations in defined GABAA receptor subtype genes in mice (knock-in strategy). New behavioural phenotypes were generated which reflect various brain disorders. In addition, novel drug targets were identified for the treatment of anxiety disorders, sleep disturbances, memory deficits, and schizophrenia.
How to Cite
H. Möhler, Chimia 2004, 58, 718, DOI: 10.2533/000942904777677461.
Copyright (c) 2004 Swiss Chemical Society
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