Functionalizable Oligoprolines as Molecular Scaffolds

Authors

  • Yvonne A. Nagel Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel
  • Michael Kuemin Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel
  • Helma Wennemers Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel

DOI:

https://doi.org/10.2533/chimia.2011.264

PMID:

21678776

Keywords:

Azidoproline, Functionalization, Molecular scaffolds, Oligoprolines, Peptides

Abstract

Azidoproline (Azp) containing oligoprolines are conformationally well-defined, helical molecular scaffolds that allow for facile functionalization. Within this article we describe the synthesis of Azp-containing oligoprolines and different strategies to introduce functional moieties. In addition, the influence of factors such as substituents at the γ-position of proline as well as functional groups at the termini on the conformational stability of the molecular scaffolds are briefly presented.

CHIMIA Vol. 65 No. 4 (2011): Laureates: Awards and Honors SCS Fall Meeting

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Published

2011-04-27

Issue

Vol. 65 No. 4 (2011): Laureates: Awards and Honors SCS Fall Meeting 2010

Section

Scientific Articles

License

Copyright (c) 2011 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Y. A. Nagel, M. Kuemin, H. Wennemers, Chimia 2011, 65, 264, DOI: 10.2533/chimia.2011.264.