Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol

Authors

  • James K. Whitesell Department of Chemistry The University of Texas at Austin Austin, TX 78712 (USA)
  • Robert M. Lawrence Department of Chemistry The University of Texas at Austin Austin, TX 78712 (USA)

DOI:

https://doi.org/10.2533/chimia.1986.318

Abstract

Commercially available, crude pig liver material (Pig Liver Acetone Powder, PLAP) is demonstrated to be effective for the preparation of enantiomerically pure alcohols that are, in turn, effective chiral auxiliaries for asymmetric induction. Resolution of the title alcohols in large scale is effected by selective enzymatic cleavage of the corresponding acetic acid esters.

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Published

1986-09-30

Issue

Vol. 40 No. 9 (1986): Forschung/Research

Section

Articles

License

Copyright (c) 1986 James K. Whitesell

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
J. K. Whitesell, R. M. Lawrence, Chimia 1986, 40, 318, DOI: 10.2533/chimia.1986.318.