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Found 40 items.
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The NCCR TransCure: An Incubator for Interdisciplinary Research
... words that best represent the NCCR TransCure network and activity. doi:10.2533/chimia.2022.992 Chimia ..." -
Boron in Medicinal Chemistry: Powerful, but Neglected Medicinal Chemistry and Chemical Biology Highlights
... Columns CHIMIA 2019, 73, No. 7/8 637 doi:10.2533/chimia.2019.637 Chimia 73 (2019) 637–638 © Swiss ..." -
Fostering Research Synergies between Chemists in Swiss Academia and at Novartis
... 936 CHIMIA 2021, 75, No. 11 Industry-AcAdemIc PArtnershIPs doi:10.2533/chimia.2021.936 Chimia 75 ..." -
Perspectives and Opportunities in Medicinal Chemistry: A View from the Novartis Institute for BioMedical Research Institute in Basel, Switzerland A Perspective on Chemistry and Society : A Column on the Occasion of the 75th Anniversary of CHIMIA
... 75th AnniversAry of ChimiA CHIMIA 2021, 75, No. 12 1091 doi:10.2533/chimia.2021.1091 Chimia 75 ..." -
Contributions of Biomolecular NMR to Allosteric Drug Discovery
... Drug discovery is a complex process, and a variety of technologies contribute to its SCS LaureateS and awardS & FaLL Meeting 2015 CHIMIA 2015, 69, No. 7/8 421 doi:10.2533/chimia ..." -
Precision-engineered Peptide and Protein Analogs: Establishing a New Discovery Platform for Potent GPCR Modulators
... of therapeutic interest. GPCRs are considered to be highly tractable for drug discovery, representing the targets PePtide Chemistry in switzerland CHIMIA 2021, 75, No. 6 489 doi:10.2533/chimia.2021.489 Chimia 75 ..." -
The Societal and Scientific Importance of Inclusivity, Diversity, and Equity in Machine Learning for Chemistry
... , shared doi:10.2533/chimia.2023.56 Chimia 77 (2023) 56–61 © D. Probst ArtificiAl intelligence ..." -
The Bitter Taste Receptor TAS2R14 as a Drug Target
... on the 108 unique GPCR targets comprises 475 doi:10.2533/chimia.2022.418 Chimia 76 (2022) 418–424 © L. A. W ..." -
BaseLaunch - How to Launch and Build Exceptional Biotech Companies Medicinal Chemistry and Chemical Biology Highlights
... 704 CHIMIA 2022, 76, No. 7/8 Columns doi:10.2533/chimia.2022.704 Chimia 76 (2022) 704–706 © Swiss ..." -
Fantastic Molecular Glues and Where to Find them Medicinal Chemistry and Chemical Biology Highlights
... doi:10.2533/chimia.2021.439 Chimia 75 (2021) 439–441 © Swiss Chemical Society Fantastic Molecular ..." -
Generating Bioactive Natural Product-inspired Molecules with Machine Intelligence
... -inspired drug discovery. and costly total syntheses (economical sustainability), and an often doi:10.2533/chimia.2022.396 Chimia 76 ..." -
The Generated Databases (GDBs) as a Source of 3D-shaped Building Blocks for Use in Medicinal Chemistry and Drug Discovery
... Drug discovery is in constant need of new molecules to develop drugs addressing unmet Laureates: Junior Prizes of the sCs faLL Meeting 2019 CHIMIA 2020, 74, No. 4 241 doi:10.2533/chimia ..." -
Isolation and Identification of Actinomycetes Strains from Switzerland and their Biotechnological Potential
... oreste ghisalBa doi:10.2533/chimia.2020.382 Chimia 74 (2020) 382–390 © F. Arn, D. Frasson, I. Kroslakova ..." -
News from the DMCCB - Congress Report from the Virtual EFMC-ISMC 2021 Medicinal Chemistry & Chemical Biology Highlights
... , but also doi:10.2533/chimia.2021.1048 Chimia 75 (2021) 1048–1050 © Swiss Chemical Society Medicinal ..." -
Vitaport: A Learning and Artistic Path for Public Outreach on Transporter Biology, Health and Drug Discovery
... and LinkedIn. doi:10.2533/chimia.2022.1063 Chimia 76 (2022) 1063–1067 © V. Rossetti, J.-L. Reymond 1064 ..." -
Molecular Similarity for Drug Discovery, Target Prediction and Chemical Space Visualization
... molecular similarity is central to drug discovery and optimization. Here I review computational methods Daylight binary doi:10.2533/chimia.2022.1045 Chimia 76 (2022) 1045–1051 © J.-L.Reymond 1046 CHIMIA 2022 ..." -
Natural Products as Leads for Anticancer Drug Discovery: Discovery of New Chemotypes of Microtubule Stabilizers through Reengineering of the Epothilone Scaffold
... 8 CHIMIA 2010, 64, No. 1/2 From ChemiCal researCh to industrial appliCations doi:10.2533/chimia ..." -
De novo Molecular Design with Generative Long Short-term Memory
... Drug discovery benefits from computational models aiding the identification of new 1006 CHIMIA 2019, 73, No. 12 ArtificiAl intelligence in SwiSS chemicAl reSeArch doi:10.2533/chimia ..." -
Our Exciting Journey to ACT-451840
... 916 CHIMIA 2021, 75, No. 11 Industry-AcAdemIc PArtnershIPs doi:10.2533/chimia.2021.916 Chimia 75 ..." -
Natural Product Hybrids
... - doi:10.2533/chimia.2006.841 Hot topics 842 cHiMiA 2006, 60, No. 12 In 2000, the first complex ..." -
Targeting Phosphoinositide 3-Kinase – Five Decades of Chemical Space Exploration
... ChemiCal Biology of memBranes and signaling CHIMIA 2021, 75, No. 12 1037 doi:10.2533/chimia ..." -
News from DMCCB – Targeted Protein Degradation Medicinal Chemistry and Chemical Biology Highlights
... Columns CHIMIA 2018, 72, No. 12 903 doi:10.2533/chimia.2018.903 Chimia 72 (2018) 903–904 © Swiss ..." -
Educational Tools to Introduce Computer-Aided Drug Design to Students and to the Public at Large
... ChemiCal eduCation CHIMIA 2018, 72, No. 1/2 55 doi:10.2533/chimia.2018.55 Chimia 72 (2018) 55–61 ..." -
From Theory to Bench Experiment by Computer-assisted Drug Design
... with practical examples from drug discovery projects. 120 CHIMIA 2012, 66, No. 3 New Professors iN switzerlaNd doi:10.2533/chimia.2012.120 Chimia 66 ..." -
Impact of DNA-Encoded Chemical Library Technology on Drug Discovery
... molecule ligands derived from DELs are increas- doi:10.2533/chimia.2022.388 Chimia 76 (2022) 388–395 © M ..." -
Reverse Design toward Optimized Labeled Chemical Probes – Examples from the Endocannabinoid System
... to support drug discovery. Labeled probes carrying an additional reporter group are valuable tools to meet Medicinal cheMistry CHIMIA 2022, 76, No. 5 425 doi:10.2533/chimia.2022.425 Chimia 76 (2022) 425 ..." -
Chemical Biology and Drug Discovery Symposium at the LS2 Annual Meeting 2021 Medicinal Chemistry and Chemical Biology Highlights
... doi:10.2533/chimia.2021.342 Chimia 75 (2021) 342 © Swiss Chemical Society Chemical Biology and Drug ..." -
Tumor Targeting with Small Molecule-Drug Conjugates (SMDCs) – Can They be Better than ADCs? Medicinal Chemistry and Chemical Biology Highlights
... 154 CHIMIA 2018, 72, No. 3 Columns doi:10.2533/chimia.2018.154 Chimia 72 (2018) 154–155 © Swiss ..." -
Three Decades of Structure- and Property-based Molecular Design
... Roche has pioneered structure- and property-based molecular design to drug discovery 472 CHIMIA 2014, 68, Nr. 7/8 Laureates of the sCs awards and faLL Meeting 2014 doi:10.2533/chimia ..." -
Prospects for the Xenopus Embryo Model in Therapeutics Technologies
... . In addition, we are assessing possibilities of using Xenopus embryos for whole-organism-based drug discovery ..." -
Coping with Polypharmacology by Computational Medicinal Chemistry
... 648 CHIMIA 2014, 68, Nr. 9 Computational Chemistry in switzerland doi:10.2533/chimia.2014.648 ..." -
Exploring Natural Product Fragments for Drug and Probe Discovery
... Fragment-based ligand discovery is a key technology to develop lead structures for drug Medicinal cheMistry CHIMIA 2017, 71, No. 10 653 doi:10.2533/chimia.2017.653 Chimia 71 (2017) 653 ..." -
The Pharmaceutical Biochemistry Group: Where Pharmaceutical Chemistry Meets Biology and Drug Delivery
... Successful drug discovery and development of new therapeutics is a long, expensive Geneva Pharma CHIMIA 2012, 66, No. 5 313 doi:10.2533/chimia.2012.313 Chimia 66 (2012) 313–319 ..." -
Chemical Diversity of Natural Resources and the Bioactivity of their Constituents
... in drug discovery. However, the interest that the pharmaceutical industry has had in NPs has declined 324 CHIMIA 2012, 66, No. 5 Geneva Pharma doi:10.2533/chimia.2012.324 Chimia 66 (2012) 324–329 ..." -
Drugs from the Oceans: Marine Natural Products as Leads for Drug Discovery
... the potential offered by the structural diversity of marine-produced secondary metabolites for drug discovery 646 CHIMIA 2017, 71, No. 10 Medicinal cheMistry doi:10.2533/chimia.2017.646 Chimia 71 (2017) 646 ..." -
Chemical Biology and Synthesis: The Spring Meeting of the Swiss Chemical Society, March 10th, 2005, Department of Chemistry and Biochemistry, University of Bern Conference Reports
... ) to investigate biologically relevant problems. Keywords: Chemical biology · Drug discovery · Fluorous chemistry ..." -
Deliberations on Natural Products and Future Directions in the Pharmaceutical Industry
... in oncology indications. The innovation of low molecular weight compounds in modern drug discovery is built 620 CHIMIA 2021, 75, No. 7/8 SCS LaureateS and awardS & FaLL Meeting 2021 doi:10.2533/chimia ..." -
Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute
... In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently doi:10.2533/chimia.2023.582 Chimia 77 (2023) 582–592 © L. Meier et al. SwiSS TPH: 30 YearS of Drug ..." -
SpeedScreen, a Label-Free, Affinity-Based High-Throughput Screening Technology for the Discovery of Orphan Protein Ligands
... · Drug discovery · HTS · LC/MS-based affinity selection · Orphan targets Introduction Currently ..." -
Computational Pharmaceutical Chemistry – Novel Technologies for Lead Optimization and the Prediction of ADMET Properties
... drug discovery · Flexible docking · Multidimensional QSAR · Prediction of binding affinities ..."
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