-
Keyword
- natural products (37)
- natural product (7)
- drug discovery (6)
- asymmetric catalysis (4)
- organic synthesis (4)
- chemical biology (3)
- mass spectrometry (3)
- advanced materials (2)
- alkaloids (2)
- antibiotics (2)
- biosynthesis (2)
- cyanobacteria (2)
- dereplication (2)
- epothilones (2)
- hplc-based activity profiling (2)
-
Author
- karl gademann (8)
- karl-heinz altmann (5)
- jean-luc wolfender (3)
- emerson ferreira queiroz (2)
- erick m. carreira (2)
- erik jung (2)
- götz schlotterbeck (2)
- herbert waldmann (2)
- jürg gertsch (2)
- kurt hostettmann (2)
- nicolai cramer (2)
- peter ertl (2)
- philippe christen (2)
- philippe renaud (2)
- silvio roggo (2)
- Publication Date
Search
Order results by:
Search Results
Found 55 items.
-
Derivation of Rapamycin: Adventures in Natural Product Chemistry
... and chemically very sensitive natural product. Despite the limitations regarding the reaction conditions SCS LaureateS and awardS & FaLL Meeting 2019 CHIMIA 2019, 73, No. 7/8 581 doi:10.2533/chimia ..." -
Arenophile-Mediated Photochemical Dearomatization of Nonactivated Arenes
... highlighted by the facile syntheses of natural products and bioactive compounds through novel disconnections. SCS LaureateS and awardS & FaLL Meeting 2020 CHIMIA 2020, 74, No. 7/8 577 doi:10.2533/chimia ..." -
Clinically Approved Antibiotics from 2010 to 2022
... , delafloxacin, tedizolid), nine natural product derivatives (ceftaroline fosamil, cefiderocol, plazomicin :10.2533/chimia.2023.230 Chimia 77 (2023) 230–234 © E. Jung, K. Gademann Fig. 1. Synthetic antibiotics ..." -
Pharmacophore-Based Screening for the Successful Identification of Bio-Active Natural Products
... discovery from natural products. Confronted by an increasing number of secondary metabolites Austria doi:10.2533/chimia.2007.350 NATURAL PRODUCTS IN DRUG DISCOVERY 351 CHIMIA 2007, 61, No. 6 ..." -
Recent Advances in Mode of Action and Biosynthesis Studies of the Clinically Used Antibiotic Fidaxomicin
... The natural product antibiotic fidaxomicin is a marketed drug for the treatment 270 CHIMIA 2020, 74, No. 4 Laureates: Junior Prizes of the sCs faLL Meeting 2019 doi:10.2533/chimia ..." -
Generating Bioactive Natural Product-inspired Molecules with Machine Intelligence
... to generate natural product-inspired bioactive compounds from scratch. A virtual chemist transforms and costly total syntheses (economical sustainability), and an often doi:10.2533/chimia.2022.396 Chimia 76 ..." -
Molecular Complexity for Chemical Reactions Medicinal Chemistry and Chemical Biology Highlights
... of Medicinal Chemistry and Chemical Biology A Division of the Swiss Chemical Society doi:10.2533/chimia ..." -
Mapping Out Biogenetic Hypotheses by Chemical Synthesis
... Synthesis of natural products via their postulated or established biosynthetic Natural Products: source of INNovatIoN CHIMIA 2017, 71, No. 12 841 doi:10.2533/chimia.2017.841 ..." -
A Simple Method for High-Throughput Extract Prefractionation for Biological Screening
... The screening of crude natural product extracts can be problematic, especially in enzyme occupied by NPs doi:10.2533/chimia.2007.327 NATURAL PRODUCTS IN DRUG DISCOVERY 328 CHIMIA 2007, 61 ..." -
Metabolomics in Ecology and Bioactive Natural Products Discovery: Challenges and Prospects for a Comprehensive Study of the Specialised Metabolome
... of bioactive natural products (NPs). The identification of metabolites is a common/central objective in both natural sources and chemical ecology. doi:10.2533/chimia.2022.954 Chimia 76 (2022) 954–963 © J.-L ..." -
Cheminformatic Analysis of Natural Products and their Chemical Space
... and characteristic properties of natural products (NPs) and comparison with related characteristics of drugs in gener- doi:10.2533/chimia.2007.355 NATURAL PRODUCTS IN DRUG DISCOVERY 356 CHIMIA 2007, 61, No. 6 ..." -
Chemical Interference of Biological Systems with Natural Products
... life on a molecular level. In this account, an overview over different natural products investigated NCCR ChemiCal Biology CHIMIA 2011, 65, No. 11 835 doi:10.2533/chimia.2011.835 Chimia 65 (2011) 835 ..." -
Plants as a Source of Therapeutic and Health Products
... of natural products, as well as herbal dietary supplements. One of the focuses relies on finding new cancer 320 CHIMIA 2012, 66, No. 5 Geneva Pharma doi:10.2533/chimia.2012.320 Chimia 66 (2012) 320–323 ..." -
Enantioselective Diels-Alder Reactions of Unsaturated ?-Ketoesters Catalyzed by Chiral Ruthenium PNNP Complexes
... Laureates: awards and Honors, sCs FaLL Meeting 2010� CHIMIA�2011,�65,�No.�4� 231 doi:10.2533/chimia ..." -
Syntheses and Biological Activity of the HDAC Class I Inhibitor Largazole
... the potential to combat cancer on an epigenetic level. The recently reported marine natural product largazole Young AcAdemics in switzerlAnd PArt i CHIMIA 2009, 63, No. 1/2 19 doi:10.2533/chimia.2009.19 ..." -
Cyanobacterial Natural Products for the Inhibition of Biofilm Formation and Biofouling
... :10.2533/chimia.2007.373 NATURAL PRODUCTS IN DRUG DISCOVERY 374 CHIMIA 2007, 61, No. 6 process. Passive ..." -
Out in the Green: Biologically Active Metabolites Produced by Cyanobacteria
... 416 CHIMIA 2011, 65, No. 6 NutritioN Chemistry iN switzerlaNd doi:10.2533/chimia.2011.416 ..." -
A General Copper-based Photoredox Catalyst for Organic Synthesis: Scope, Application in Natural Product Synthesis and Mechanistic Insights
... OrganOmetallics and catalysis CHIMIA 2018, 72, No. 9 621 doi:10.2533/chimia.2018.621 Chimia 72 ..." -
Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development
... and spongouridine. These sponge-derived natural products initiated a chain of events that has resulted in countless environment. The oceans are populated with a wealth of ani- doi:10.2533/chimia.2007.313 Kahalalide ..." -
J-based Configuration Analysis: An Enabling NMR-Spectroscopic Tool in the Synthesis and Study of Chlorinated Natural Products Highlights of Analytical Chemistry in Switzerland
... Phone: +41 58 765 77 87, Fax: +41 58 765 77 62, Mail to: veronika.meyer@empa.ch doi:10.2533/chimia ..." -
New Tubulin Inhibitors from Plants – A Critical Assessment
... -derived natural products that were recently reported to be microtubule-stabilizing agents were found doi:10.2533/chimia.2007.368 NATURAL PRODUCTS IN DRUG DISCOVERY 369 CHIMIA 2007, 61, No. 6 gin ..." -
Efficient Structure Elucidation of Natural Products in the Pharmaceutical Industry
... The procedure of structure elucidation of natural products at Novartis is discussed in the last decade.[5,6] The emergence of high-throughput screening and combi- doi:10.2533/chimia.2007.346 ..." -
Deliberations on Natural Products and Future Directions in the Pharmaceutical Industry
... Natural Products are molecular “special equipment” that impart survival benefits 620 CHIMIA 2021, 75, No. 7/8 SCS LaureateS and awardS & FaLL Meeting 2021 doi:10.2533/chimia ..." -
Natural Products as Leads for Anticancer Drug Discovery: Discovery of New Chemotypes of Microtubule Stabilizers through Reengineering of the Epothilone Scaffold
... and their individual structures show little divergence from the original natural product leads. In contrast, we have 8 CHIMIA 2010, 64, No. 1/2 From ChemiCal researCh to industrial appliCations doi:10.2533/chimia ..." -
Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products
... The rapid acquisition of structural and bioactivity information on natural products (NPs Laureates: awards and Honors, sCs FaLL Meeting 2011 CHIMIA 2012, 66, No. 4 229 doi:10.2533/chimia ..." -
Burning the Hay to Find the Needle – Data Mining Strategies in Natural Product Dereplication
... for different data mining strategies: i) the dereplication of previously isolated natural products; ii , have a strong need for the identification of compounds in complex extracts. doi:10.2533/chimia ..." -
Natural Product Hybrids
... This review highlights several classes of natural product hybrids First, structural - doi:10.2533/chimia.2006.841 Hot topics 842 cHiMiA 2006, 60, No. 12 In 2000, the first complex ..." -
Novel Analytical Workflow for Comprehensive Non-targeted Phytochemical Metabolic Profiling FH-HES
... 294 CHIMIA 2015, 69, No. 5 Columns doi:10.2533/chimia.2015.294 Novel Analytical Workflow ..." -
Uncovering Novel Peptide Chemistry from Bacterial Natural Products
... chemistries into natural products (NPs), bestowing them with a range of important biological properties PePtide Chemistry in switzerland CHIMIA 2021, 75, No. 6 543 doi:10.2533/chimia.2021.543 Chimia 75 ..." -
The Development of Biocatalysis as a Tool for Drug Discovery
... and the production of biocatalytically modified natural products, which all play a role in drug discovery oreste ghisalBa doi:10.2533/chimia.2020.368 Chimia 74 (2020) 368–377 © J. Schwarz, K. Rosenthal, R ..." -
From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of α-Aryl-α-isocyanoacetate to Vinyl Phenyl Selenone
... Laureates of the sCs faLL Meeting 2013 CHIMIA 2014, 68, Nr. 4 211 doi:10.2533/chimia.2014.211 ..." -
Recent Advances in Iridium-Catalyzed Asymmetric Hydrogenation: New Catalysts, Substrates and Applications in Total Synthesis
... -catalyzed asymmetric hydrogenation in the formal synthesis of the natural product Platensimycin. Laureates: awards and Honors, sCs FaLL Meeting 2011 CHIMIA 2012, 66, No. 4 187 doi:10.2533/chimia ..." -
The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides
... A short route to the synthesis of analogues of the antifungal but unstable natural product Chemische Gesellschaft ISSN 0009–4293 The Crocacins: Novel Natural Products as Leads for Agricultural ..." -
Catalytic Asymmetric Functionalization of Inert Bonds and Synthesis of Bioactive Natural Products
... 656 CHIMIA 2011, 65, No. 9 EPF LausannE doi:10.2533/chimia.2011.656 Chimia 65 (2011) 656–658 ..." -
Cysteine-specific Chemical Proteomics: From Target Identification to Drug Discovery
... the direct biological targets of curcumin, a diarylheptanoid natural product with anticancer activity 764 CHIMIA 2016, 70, No. 11 New Faculty iN SwitzerlaNd doi:10.2533/chimia.2016.764 Chimia 70 (2016 ..." -
Host Marking Pheromone (HMP) in the Mexican Fruit Fly Anastrepha ludens
... into the valuable commodity. Having no insecticidal or toxic properties, and being natural products (or close From ChemiCal researCh to industrial appliCations� CHIMIA�2010,�64,�No.�1/2� 37 doi:10.2533/chimia ..." -
Following the Lead from Nature with Covalent Inhibitors
... and many natural products possess mildly electrophilic moieties able to covalently engage a target protein Medicinal cheMistry CHIMIA 2017, 71, No. 10 703 doi:10.2533/chimia.2017.703 Chimia 71 (2017) 703 ..." -
Accelerated Dereplication of Natural Products, Supported by Reference Libraries
... Natural products are an indispensable source for drug discovery. The major challenge :10.2533/chimia.2007.332 NATURAL PRODUCTS IN DRUG DISCOVERY 333 CHIMIA 2007, 61, No. 6 put screening ..." -
Tricyclic Marine Alkaloids: Synthetic Approaches to Cylindricines, Lepadiformine, and Fasicularin
... features make these alkaloids interesting targets for natural product synthesis. This review focuses interesting targets for natural product synthesis. This review focuses on the different approaches developed ..." -
From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents
... · DNA gyrase inhibitor · Natural products The identification of DNA gyrase [1] as the biological target ..." -
Discovery and Study of New Reaction Chemistry; Applications in Complex Molecule Assembly
... adducts in useful yields and excellent enantio-induction. The application of this method to natural and excellent enantio-induction. The application of this method to natural products syntheses, as exemplified ..." -
Thin-layer Chromatography–Nuclear Magnetic Resonance Spectroscopy – A Versatile Tool for Pharmaceutical and Natural Products Analysis FH – HES Universities of Applied Sciences
... used in many fields of applications ranging from natural product analysis to chemical or pharmaceutical Columns CHIMIA 2012, 66, No. 5 347 doi:10.2533/chimia.2012.347 Universities of Applied Sciences ..." -
Exploring Natural Product Fragments for Drug and Probe Discovery
... demand of fragments with stereogenic centers. Natural products (NPs) are evolutionary selected ligands Medicinal cheMistry CHIMIA 2017, 71, No. 10 653 doi:10.2533/chimia.2017.653 Chimia 71 (2017) 653 ..." -
Chemical Diversity of Natural Resources and the Bioactivity of their Constituents
... Natural products (NPs) have historically been an important source of lead molecules 324 CHIMIA 2012, 66, No. 5 Geneva Pharma doi:10.2533/chimia.2012.324 Chimia 66 (2012) 324–329 ..." -
Natural Products in the Discovery of Agrochemicals
... Natural products have a long history of being used as, or serving as inspiration 810 CHIMIA 2017, 71, No. 12 Natural Products: source of INNovatIoN doi:10.2533/chimia.2017.810 ..." -
From Solution-Phase Studies to Solid-Phase Synthesis: A New Indole Based Scaffold for Combinatorial Chemistry
... The core structure of a natural product was selected as scaffold for combinatorial library : The core structure of a natural product was selected as scaffold for combinatorial library synthesis ..." -
Investigation of Medicinal Plants for the Treatment of Neglected Diseases
... , natural products constitute a reservoir of new molecules with potential therapeutic interest. An outline limited. In this field, natural products constitute a reservoir of new molecules with potential ..." -
Radical Reactions as a Tool for Natural Product Synthesis
... Four examples of the synthesis of simple natural products and analogues bearing several © Schweizerische Chemische Gesellschaft ISSN 0009-4293 Radical Reactions as a Tool for Natural Product Synthesis ..." -
Drugs from the Oceans: Marine Natural Products as Leads for Drug Discovery
... marine natural products are known, of which eight are (were) at the origin of seven marketed drugs 646 CHIMIA 2017, 71, No. 10 Medicinal cheMistry doi:10.2533/chimia.2017.646 Chimia 71 (2017) 646 ..." -
Spectral Aliasing: A Super Zoom for 2D-NMR Spectra. Principles and Applications
... 2D heteronuclear experiments to the study of natural products and synthesis intermediates are shown Young AcAdemics in switzerlAnd PArt iii� CHIMIA�2010,�64,�No.�4� 235 doi:10.2533/chimia.2010.235 ..."